Fri Jun 27 2025

37 articles - From Friday Jun 20 2025 to Friday Jun 27 2025

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

Liver Transpl

Prognostic and diagnostic biomarkers in liver transplantation: A systematic review and meta-analysis.

Additionally, we identified novel combinations of biomarkers that exhibited prognostic value for LT patients. Finally, we demonstrate that combined analytical tools for assessing large clinical datasets effectively evaluate multi-modal markers for risk stratification of early and late outcomes for LT.

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Pancreas

Comparison of Biliary Drainage Techniques for MBO: A Meta-Analysis.

PTBD may offer advantages over EBD in managing MBO, including fewer complications and reduced incidence of pancreatitis, suggesting PTBD as a potentially safer and more effective treatment option. Nonetheless, further large-scale, high-quality studies are needed to validate these findings.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Clin Nutr

Adherence to the Modified Planetary Health Diet among the Working-Age Population in 185 Countries from 1990 to 2018: A Population-Based Study.

Our findings reveal substantial global variations in mPHD adherence among WAP, with concerning trends in certain regions. These results provide crucial insights for developing targeted interventions that consider regional contexts while pursuing the dual objectives of promoting healthier diets and ensuring environmental sustainability.

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Gestational vitamin D concentration and child cognitive development: A longitudinal cohort study in the ECHO Program.

Gestational 25(OH)D concentrations were positively associated with cognitive scores, especially in children of Black mothers. Given higher deficiency risk among Black women, vitamin D repletion prior to or in early pregnancy may be an important strategy for reducing racial disparities in child neurodevelopment.

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Novel Strategies for Medical Management of Obesity: Mechanisms, Clinical Implications, and Societal Impacts: a report from the 25<sup>th</sup> annual Harvard Nutrition Obesity Symposium.

Recent work also points out to the potential role of these medications for other medical conditions, including addictive and neurodegenerative disorders. In June 2024, the NIH-funded Nutrition Obesity Research Center at Harvard and the Harvard Medical School Division of Nutrition hosted their 25th annual Harvard Nutrition Obesity Symposium, titled "Novel Strategies for Medical Management of Obesity: Mechanisms, Clinical Implications, and Societal Impacts." This article synthesizes the symposium's discussions, emphasizing the importance of innovative pharmacotherapeutic strategies in addressing the burden of obesity and the associated economic and social inequities, including disparities in access to care in adults and children.

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Prospective association of the EAT-Lancet reference diet with body weight changes and incidence of overweight and obesity in a French cohort.

This comprehensive prospective observational study revealed that a stronger adherence to the EAT-Lancet reference diet is associated with a lower body weight and reduced risks of overweight and obesity. Promoting a sustainable plant-based diet seems to be an effective strategy for addressing the global public health challenge of obesity.

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Inflamm Bowel Dis

Early Top-Down Treatment With Biologics Improves the Rates of Transmural Remission in Crohn's Disease-A Risk-Adjusted Propensity Score Matched Analysis.

Early top-down treatment with biologics improves the rates of transmural remission in CD. Risk factors for disabling disease significantly impact the chances of obtaining transmural remission and may help clinicians identify patients suitable for more aggressive treatment strategies.

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Inflammation of the Rectal Cuff is Associated With Strictures and Fistulas in Patients With Ulcerative Colitis who Have an Ileal Pouch-Anal Anastomosis.

Endoscopic cuff inflammation is associated with strictures and fistulas of the IPAA, and individuals with persistent inflammation appear to have the highest risk.

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Long-Term Outcome of Colonic and Ileal Crohn's Disease: A Two-Decade Population-Based Study in Pediatric-Onset Disease.

The clinical presentation and evolution of ileal and colonic CD differ significantly in children. Colonic location is associated with a high risk of perianal CD, extraintestinal manifestations, and exposure to steroids, immunosuppressants, and anti-TNFs. These differences could justify different therapeutic approaches.

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Natural History, Treatment Persistence and Predictors of Treatment Failure in Patients With Ulcerative Colitis on 5-Aminosalicylic Acid: A US Population-Level Cohort Study.

Our study provides updated estimates of advanced therapy utilization and colectomy as well as predictors of disease progression in patients with UC on 5-ASA in the biologic era.

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Pou2af1 Deficiency Aggravates DSS-Induced Colitis via Impaired Germinal Center Responses and Altered Gut Microbiota.

The findings suggest that Pou2af1 deficiency exacerbates DSS-induced colitis by impairing immune responses, particularly the germinal center reaction, and altering gut microbiota composition. These alterations contribute to increased disease severity, highlighting the importance of Pou2af1 in maintaining intestinal immune homeostasis.

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Prostaglandins and Inflammatory Bowel Disease: From Mechanism to Clinic.

As a result, therapeutic approaches focusing on PGs and the pathways contributing to their synthesis have become a primary objective in IBD treatment research. This paper intends to examine the significance of PG receptors in IBD, providing a fresh viewpoint for understanding the pathogenesis of the disease and establishing a theoretical basis for creating diagnostic tools and treatment strategies centered around PG targets to improve patient outcomes.

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Liver Transpl

Comparing donor selection barriers for living donor liver transplantation amongst hispanic and non-hispanic candidates in a large urban center.

LDLT disparities among Hispanics may involve factors preceding donor evaluation or independent of the donor. Optimizing Hispanic LLD candidacy, establishing a registry of individuals referred for LLD, and conducting multicenter studies are warranted.

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The incidence of severe complications in liver donation from living donors: Real-world data in the era of minimally invasive surgery.

Overall incidence of severe complications in liver donation was comparable between open and MIS approach. The site of postoperative bleeding differed by surgical approach, suggesting potentially need of different care for MIS to reduce the postoperative complication in donor hepatectomy.

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Pancreas

Analysis of Influencing Factors of Acute Pancreatitis Complicated with Persistent Inflammation and Construction of a Prediction Model.

The model predicted non-SIRS with a critical value ≥0.332, a sensitivity of 71.3% and specificity of 87.1%, and a Kappa value of 0.56. These results indicate that this prediction model is based on admission data, with recommended additional validation assessments at multiple time points (e.g., 24, 48, and 72 h) to characterize the progression of SIR's risk fully. Overall, this nomogram prediction model provides an efficient and simple means to predict SIRS for patients with AP.

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Gastrointestinal Burden in Patients with Pancreatic Insufficient Cystic Fibrosis Before and After Elexacaftor/Tezacaftor/Ivacaftor Use.

The reduction in constipation and non-infective gastroenteritis and colitis is important as GI symptoms are linked to the quality of life of CwCF. There remains a great clinical need to evaluate the effects of ETI on GI disorders, especially as the age of initial use of this therapy decreases, and the duration of use increases.

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Lifetime Smoking History and Marijuana co-use in Patients With Alcohol-related Acute Pancreatitis.

Smoking is highly prevalent in patients with alcohol-associated AP, many of whom also use marijuana. Tailored smoking cessation interventions are needed for AP patients.

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Long Non-Coding RNA n336928 Facilitates the Progression of Pancreatic Neuroendocrine Neoplasms via NF-κB Pathway Mediated by EZH2.

Furthermore, transcriptome sequencing revealed that the NF-κB pathway was activated in pNEN cells following n336928 overexpression. We have established that the upregulation of n336928 promotes the progression of pNENs via the NF-κB signaling pathway, thereby implicating it in the occurrence and development of pNENs.

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rs928508 of miR-30c-5p is Associated with the Risk of Post-ERCP Pancreatitis.

miR-30c-5p rs928508 polymorphism is correlated with an enhanced risk and severity of PEP.

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Pancreatology

A Mendelian randomization study investigating the causal effect of simvastatin consumption on pancreatitis risk.

Genetic evidence has not proven a causality between simvastatin and pancreatitis, suggesting that routine monitoring may be unnecessary.

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Clinical predictors of KRAS mutation detection in liquid biopsies for pancreatic ductal adenocarcinoma.

CA19-9 levels and hepatic metastases are predictive of KRAS mutation detection in ctDNA. Higher Max VAF may reflect more aggressive disease biology in PDAC.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Am J Clin Nutr

Glycemic sensitivity-a potential biomarker for healthy people.

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Inflamm Bowel Dis

The Dual Role of ACE2 in IBD: Balancing SARS-CoV-2 Susceptibility and Gut Homeostasis.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Inflamm Bowel Dis

Efficacy of Risankizumab Dose Escalation Among Patients With Inflammatory Bowel Disease.

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Liver Transpl

Cannabis and Liver Transplant: We Need to Chill, Man.

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Every last detail-Managing hepatic artery thrombosis and stenosis in a time of organ scarcity.

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Home-based terlipressin as a therapy for ascites: Increasing evidence for the efficacy of long-term continuous terlipressin infusion in decompensated cirrhosis.

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Letter to the Editor: Accurately predict the HCC recurrence after liver transplantation.

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Letter to the Editor: Continuous Infusion terlipressin for refractory ascites-key considerations for future trials.

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No change in alcohol relapse after adoption of early liver transplantation for alcohol-associated liver disease.

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Normothermic machine perfusion - The juice is definitely worth the squeeze.

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Reply: Continuous Infusion terlipressin for refractory ascites-key considerations for future trials.

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Pancreas

The Prevalence and Characteristics of Autoimmune Pancreatitis among Patients Presenting with Pancreatitis to a Quaternary Referral Centre in Melbourne, Australia.

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Pancreatology

Clinicopathological features for clinically resectable peripherally located pancreatic ductal adenocarcinoma.

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Letters&Replies

Letters to the editors and authors’ replies

Pancreatology

A real-world analysis of second-line treatment option, Gemcitabine plus Anlotinib and anti-PD1, in advanced pancreatic cancer: A critical insight.

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Comment on "A causal relationship between distinct immune features and acute or chronic pancreatitis: Results from a Mendelian randomization analysis".

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Letter to Editor: Strengths and methodological Considerations for Predicting post-pancreatectomy acute pancreatitis.

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